Acetylation Reaction | Definition, Mechanism & Examples

Dr Vandana Puri on Instagram: "HDAC inhibitors (HDACi) are drugs that increase histone acetylation, leading to open chromatin and increased gene expression.HDAC enzymes normally remove acetyl groups → chromatin becomes tight → genes OFF HDAC inhibitors block this removal → chromatin becomes open → genes ON Common HDAC Inhibitors Vorinostat (SAHA) Romidepsin Panobinostat Belinostat Valproic Acid Vorinostat (SAHA) FDA-approved for cutaneous T-cell lymphoma. 2. Romidepsin Also used for T-cell lymph

RN.Yasmeen Abughazleh on Instagram: "🧬 Your genes don’t change… but how they behave DOES 👀 Welcome to epigenetics. 🧠 EPIGENETICS: How genes turn ON & OFF Epigenetics explains how lifestyle and environment can control gene expression without changing DNA 👇 🔕 Gene silencing (OFF) • DNA methylation • Tight chromatin → no transcription 🔔 Gene expression (ON) • Histone acetylation • Open chromatin → mRNA made 🥗 Stress, diet, toxins, exercise, and aging all play a role 👯‍♂️ Same DNA ≠ same out