Ultragenyx Pharma announces phase 3 Orbit & Cosmic results for setrusumab in osteogenesis imperfecta: Novato, California Wednesday, December 31, 2025, 18:00 Hrs [IST] Ultragenyx P ...

Ultragenyx is developing setrusumab in pediatric and young adult patients across OI sub-types I, III and IV with two late-stage studies: the pivotal Phase 2/3 Orbit study and Phase 3 Cosmic study.

Neither study achieved its primary endpoint of reduction in annualized clinical fracture rate compared to placebo (ORBIT) or bisphosphonates ...

Inflammation covertly rewires the bone marrow, enabling mutated stem cells to rise and setting the stage for future blood disease.

Neither study achieved its primary endpoint of reduction in annualized clinical fracture rate compared to placebo (Orbit) or bisphosphonates (Cosmic) Both studies achieved the secondary endpoint of im ...

Neither study achieved its primary endpoint of reduction in annualized clinical fracture rate compared to placebo (ORBIT) or bisphosphonates (COSMIC) Both studies achieved secondary endpoint of improv ...

In Bob Odenkirk’s latest action thriller, he discovers that his small town is far from “Normal.” Odenkirk reteamed with his “Nobody” writer Derek Kolstad and producer Marc Provissiero (also from ...

Ruben Amorim did not confirm whether Manchester United will play against Bournemouth with a different formation. Amorim has been wedded to his 3-4-3 formation since his appointment from Sporting ...

Manchester United manager Ruben Amorim is reportedly planning to make big changes to his team for the Premier League game against Bournemouth. Since replacing Erik ten Hag at Old Trafford, Amorim has ...

Please Note: All times UK. Tables are subject to change. The BBC is not responsible for any changes that may be made. Manager: John Coleman Formation: 4 - 3 - 3 Manager: Greg Lincoln Formation: 4 - 2 ...

Manchester United were at their very best and their very worst in an illogical but hugely entertaining 4-4 draw at home to Bournemouth. Amad Diallo and Casemiro gave United the lead either side of ...

Please Note: All times UK. Tables are subject to change. The BBC is not responsible for any changes that may be made. Manager: Peter Zeidler Formation: 4 - 1 - 2 - 1 - 2 Manager: Mario Frick Formation ...