Nonsense mutations, that convert a sense codon into a premature termination codon (PTC), are associated with a range of devastating genetic diseases. tRNA-based therapies aim to alter an anticodon of ...
Figure 1: Stop-codon specificity of RF1 and RF2 in termination. Earlier hypotheses have ascribed the dual second-position specificity of RF2 to the ability of Ser 193 to form bifurcated hydrogen bonds ...
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