Cells constantly monitor and recycle their proteins through a tightly regulated waste-disposal system. Proteins that are no ...

Molecular glues are enjoying the spotlight, but discovering new ones is often a matter of luck. A new method, developed by ...

Age-related changes in protein tagging and degradation may help explain how the brain declines over time and why diet can still influence these processes.

A new active substance attacks a key protein in tumor cells, leading to complete degradation. In cell experiments, this caused cancer cells to lose their protection and die. The active substance was ...

In this Teach Me in 10, Dr. Sam Jensen provides a comprehensive overview of the tools, assays and strategies needed at each ...

Edited by: Thomas W. Durso and Karen Young Kreeger M. Hochstrasser, "Ubiquitin, proteasomes, and the regulation of intracellular protein degradation," Current Opinion in Cell Biology, 7:215-23, 1995. ...

Origami is collaborating with Ipsen to develop molecules designed to remove or correct abnormal proteins in neurodegenerative diseases.

Drug resistance continues to limit the long-term benefit of many targeted therapies and chemotherapies against cancer. While “classical” small-molecule ...

The webcast can be accessed under “Events and Presentations” on the investor page of the Arvinas website. A replay of the webcast will be available on the Arvinas website at following the completion ...

There is no known cure for Huntington's disease. A genetic mutation creates harmful proteins that accumulate and cause the disease's typical symptoms. A team from the Department of Human Genetics at ...