Integrin activation unbends the molecule either by ligand binding or by effects on the cytoplasmic domains which straightens and separates the legs of the molecule. This exposes activation epitopes ...
High levels of IB6 are often found in NSCLC, making it a good target for treatment. A preclinical study found that in lung cancer, IB6 was correlated with interleukin-8 levels and promoted cancer cell ...
Atherosclerosis, a disease characterized by the accumulation of lipids and inflammatory cells in the arterial wall, is a significant cause of cardiovascular events. A key process in atherosclerosis is ...
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