Circulating Tumor DNA and Biomarker Analyses From the LOTUS Randomized Trial of First-Line Ipatasertib and Paclitaxel for Metastatic Triple-Negative Breast Cancer Paired peripheral-blood samples taken ...

In an allogeneic haematopoietic cell transplant, the blood system of a recipient with a haematological disease is replaced with that of a tissue-matched donor. For many individuals with such diseases, ...

A research collaboration has published a comprehensive overview of how our immune system reshapes tumor architecture in response to immune checkpoint therapy. The eight-year study outlines how cancer ...

Cyclone tracks immune responses in cancer patients, revealing new T cell recruitment with each checkpoint inhibitor infusion. PD-1 and CTLA-4 inhibitors induce clonal T cell responses, replenishing ...

Germinal centers are high-speed evolution machines. Tiny clusters in the lymph nodes, germinal centers refine antibodies through mutation and expansion until they produce high-affinity B cells adapted ...

Tumor-infiltrating clonal hematopoiesis increased the risk of disease recurrence or death among patients with cancer. TET2 mutations were the strongest genetic predictor of tumor-infiltrating clonal ...

Study reveals how our immune system transforms across a lifetime—unlocking the potential for predicting disease risk and optimizing health before symptoms appear. Resource: Integrating single-cell RNA ...